A combined rapid acting-long acting insulin formulation has been developed
in which the pH of the rapid acting insulin is adjusted so that the long
acting glargine remains soluble when they are mixed together. In the
preferred embodiment, this injectable basal bolus insulin is administered
before breakfast, provides adequate bolus insulin levels to cover the
meal, does not produce hypoglycemia after the meal and provides adequate
basal insulin for 24 hours. Lunch and dinner can be covered by two bolus
injections of a fast acting, or a rapid acting or a very rapid acting
insulin. As a result, a patient using intensive insulin therapy should
only inject three, rather than four, times a day.