The present invention provides compounds of Formula I useful as modulators
of ABC transporter activity,
##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.B, n, B,
R.sup.C, R.sup.D, R.sup.E, A, and Z are described generally and in
classes and subclasses below.
The present invention also provides pharmaceutical compositions, methods
and kits associated with Formula I, useful for as modulators, and for the
treatments of disease and disease conditions associated with ABC
transporter proteins.
