Described are devices, methods, and kits for non-invasively measuring
glucose. In general, the devices comprise skin patches for placement on a
skin surface and measurement devices for measuring glucose collected in
the patches. The patches may include an adhesive material, a collection
layer, an interface layer, and a sweat-permeable membrane. The
sweat-permeable membrane is configured to act as a barrier to epidermal
contaminants and glucose brought to the skin surface via diffusion. In
this way, non-correlatable skin surface glucose will not be measured. The
patches may further include components to induce a local sweat response.
The measurement device typically includes a display, a processor, and a
measurement mechanism. The methods typically include the steps of wiping
the skin surface with a wipe containing at least one solvent for removing
glucose, placing a patch on a skin surface, and measuring glucose
collected in the patch. Kits comprising the patch and measurement device
are also described.