A remote response system that utilizes portable response devices that require a user to input a program code and response data, which are transmitted over existing communication systems to a central location for processing. Certain response devices communicate over wireless systems, while other response devices communicate over plain old telephone systems by sending data bursts or by dialing different, pre-established telephone numbers. A user of the response device can communicate with a presenter of programming that is live or broadcast over audio/visual mediums in real time, without requiring the user to have a personal computer.