A chemical genus of biphenyl heterocycle derivative inhibitors of LTA4H (leukotriene A4 hydrolase) of the formula: ##STR00001## is disclosed. In these compounds Q and Z are (CH.sub.2).sub.1-10; in which one or two (CH.sub.2) may optionally be replaced by --O--, --NR.sup.1--, --SO--, --S(O).sub.2--, --C(.dbd.O)-- or --C.dbd.O(NH)--; Het is a 5-7 membered non-aromatic nitrogen heterocycle; and W is acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, --COOalkyl, --CHO, heterocyclyl, substituted aryl, or substituted heterocyclyl, or taken together ZW can be H or --COOalkyl. The compounds are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.