A system and method for actively managing Type 1 diabetes mellitus on a personalized basis is provided. Models of glycemic effect for a Type 1 diabetic patient are established for both insulin time course and digestive response. A rise in postprandial blood glucose is estimated through food ingestion of a planned meal in proportion to the digestive response model. An amount of insulin necessary and timing of delivery to mediate transport of blood glucose into cells in proportion to the postprandial blood glucose rise is determined through the insulin time course model.