Mouthpieces having activated textured surfaces that can be implemented using repetitive movement mechanisms and energy (e.g., electromagnetic radiation) emitting sources are disclosed. The mouthpieces may be used to provide detection, treatment and management of conditions including tooth discoloration and periodontal disease. Implementations can include a low-profile mouthpiece or a mouthpiece covering only front sides of the upper and lower teeth. Other combinations may include full-mouth implementations suitable for simultaneously covering part or all of a patient's upper and lower rows of teeth. The activated textured surfaces may include a surface topography consisting of bristles.