A method and a corresponding apparatus for determining a position in an image, in particular a medical image enables a reliable determination of positions of interest in images of a variety of structures by displaying a volume rendering of image data acquired from an object, in particular a patient, pointing at a structure of interest displayed in the volume rendering of the image data, generating a viewing ray profile comprising information characterizing a ray running through said structure of interest, selecting a contextual profile from various contextual profiles, each of said contextual profiles comprising a representative ray profile representing a viewing ray profile of a structure, in particular an anatomical structure, and comprising profile information, and determining a position within said structure of interest based on said profile information of said selected contextual profile in the case that the representative ray profile of said selected contextual profile is matching with at least a part of said viewing ray profile.