A disk drive is disclosed comprising a disk and a head actuated over the disk. The disk drive further comprises control circuitry operable to receive a Native Command Queuing (NCQ) access command from a host, wherein the NCQ access command comprises at least one logical block address (LBA), and a tag field for identifying the access command. The tag field is evaluated to determine a size of the logical block in order to transfer the logical block between the disk drive and the host. In one embodiment, the tag field comprises a tag number selected from a range of numbers, including a first range of numbers identifying a first logical block size, and a second range of numbers identifying a second logical block size.