A system and method for check anti-fraud security includes a system installed with an optional printer for printing the check base identification, a camera/scanner/reader coupled to the production printer for imaging/scanning/reading check base identification and MICR line information of the check, a data processing equipment to generate the unique check identification based on the imaged data, a database in communication with the camera/scanner/reader for storing the unique identification information, and a check validation infrastructure in communication with the database for validating the check in accordance with the database when the check is issued to a recipient; and further includes a corresponding method for identifying a check base stock, imaging check base identification and MICR line information of the printed check, generating the unique check identification, storing the unique check identification information in a database and validating the check in accordance with the database when the check is issued to a recipient.