In a method and apparatus to determine a predetermined signal amplitude of an examination subject in an MR measurement in which multiple RF pulses are radiated into the examination subject in a pulse sequence in a pulse series with a repetition time TR that is smaller than the T.sub.2 times of the examination subject, a target magnetization is established for a predetermined point in time after radiation of the respective RF pulse for essentially all RF pulses from the pulse series, a target flip angle and a target phase are determined for different regions of the examination subject for essentially all RF pulses depending on the respective target magnetization, a respective amplitude and phase response is determined for essentially all RF pulses to generate the respective target magnetization after radiation of the respective RF pulse, and the RF pulses with the respective determined amplitude and phase response are radiated into the examination subject.