Certain embodiments of the present invention provide methods and systems for determine a level of significance of an image. Certain embodiments include selecting one or more parameters for use in determining a level of significance for an image, assigning a value to each of the one or more parameters, and determining the level of significance for the image based on the parameters and the values associated with each of the one or more parameters. One or more parameters may be weighted to affect determination of the level of significance. An offset may be added to the determination of the level of significance for the image. Parameters may include clinical relevance, diagnosis pattern, segmented area, number of pixels, and/or reading time for the image, for example.