A method for predicting a user's future glycemic state includes measuring a user's glucose concentration at intervals over a time duration, thereby generating a plurality of glucose concentrations as a function of time. First and second glucose prediction equations that are fits to the plurality of glucose concentrations based on first and second non-identical mathematical models, respectively, are then derived. The method also includes calculating first and second predicted glucose concentrations at a future time using the first and second glucose prediction equations, respectively. Thereafter, an average predicted glucose concentration and a merit index are calculated based on the first and second predicted glucose calculations. The plurality of glucose concentrations as a function of time, the merit index and average predicted glucose concentration are input into a trained model (for example, a Hidden Markov Model) that outputs a set of glucose concentration probabilities. The user's future glycemic state is then predicted based on the set of glucose concentration probabilities.