Sensors and a method for detecting an analyte are described. Sensors each
have a volume of a hydrophilic medium that retains an amount of analyte
proportionate to the concentration of analyte in a biological fluid,
electrodes and a redox enzyme in contact with medium, and an electron
transfer mediator. The fluid contacts sensors and at initially
predetermined intervals intermittently applies a potential to electrode
sufficient to oxidize the mediator and sensing current through electrode
as a function of the duration of the applied potential. The applied
mediator oxidizing applied potential is maintained for a period of time
sufficient to determine the rate of change of current with time through
electrode. The current flow is correlated with the current flow for known
concentrations of the analyte in medium.