An imaging system of an object in an imaged subject is provided. The imaging system includes an image detector and a guidewire in support of a pair of markers. The imaging system also includes a controller in communication with the image detector. The controller includes a processor in communication to execute a series of programmable instructions stored in a memory, the programmable instructions including acquiring a plurality of acquired images, detecting a position of the pair of markers, calculating a first mathematical representation of an alignment of the guidewire between the markers and a second mathematical representation of an alignment of the guidewire not between the markers, and registering the first and second mathematical representations of the guidewire extending through the object relative to more than one of the acquired images so as to locate the object in at least one of the acquired images.