[Problem] To provide a pharmaceutical, particularly a compound which can
be used as an insulin secretion promoter or a preventive or therapeutic
agent for diabetes mellitus and the like diseases in which GPR40 is
concerned.
[Means for resolution] It was found that novel carboxylic acid derivatives
or salts thereof, characterized in that carboxylic acid is linked to a
6-membered monocyclic aromatic ring via two atoms and said aromatic ring
is linked to a nitrogen-containing bicyclic ring via a linker, have
excellent GPR40 receptor agonist action. In addition, since the
carboxylic acid derivatives of the invention showed excellent insulin
secretion promoting action and blood glucose reducing action, they are
useful as an insulin secretion promoter and a preventive or therapeutic
agent for diabetes mellitus.