Embodiments of a wireless communication device and a method for reducing in-band interference in a GPS receiver are generally described herein. Other embodiments may be described and claimed. In some embodiments, an adaptive filter may be used to measure in-band interference from in-band signals generated from coupled signals of a handset transmitter. The in-band interference may be subtracted from digital GPS signals provided by the GPS receiver. In some embodiments, the in-band interference is not subtracted from the GPS signals when the handset transmitter is not active.