A driving method of a driverless peripheral device with a cross platform overcomes the inconveniences faced by users of prior art in having to install a driver and/or an application program when a peripheral device is connected with their computer. The present invention utilizes an interface of the homepage stored in a driverless peripheral device for driving the peripheral device with a cross platform. The present invention has the advantages that it doesn't require a driver for any peripheral device, nor an application program. Furthermore, it can execute the necessary operations directly and has cross platform functions.