A micro fuel cell comprises at least a substrate provided with front and rear faces. The front face of the substrate supports a successive stacking of a first electrode, a substantially flat electrolytic membrane and a second electrode. The electrolytic membrane comprises at least one anchoring element salient substantially perpendicularly to a main plane of said membrane. The anchoring element is arranged in a complementary part of an anchoring recess formed in the substrate. The substrate can also comprise a plurality of microchannels, substantially perpendicular to the main plane of the membrane. The anchoring recess can then be formed by one of the microchannels whereas the other microchannels enable supply of the first electrode with reactive fluid. Such a micro fuel cell is able to operate when a pressure difference exists between the two sides of the stacking.