The present invention relates to a scoring system for the prediction of
cancer recurrence. More particularly, the present invention concerns with
the selection of genes and/or proteins, and generation of formulae with
the selected genes and/or proteins for the prediction of cancer
recurrence by measuring the expression of genes and/or proteins of human
tumor tissues, and comparing their patterns with those of the gene and/or
protein expression of human primary tumors from patients who have cancer
recurrence and those who do not have cancer recurrence. The present
invention also relates to a kit for performing the method of the present
invention comprising DNA chip, oligonucleotide chip, protein chip,
peptides, antibodies, probes and primers that are necessary for effecting
DNA microarrays, oligonucleotide microarrays, protein arrays, northern
blotting, in situ hybridization, RNase protection assays, western
blotting, ELISA assays, reverse transcription polymerase-chain reaction
(hereinafter referred to as RT-PCR) to examine the expression of at least
2 or more of genes and/or proteins, preferably 4 or more of genes and/or
proteins, more preferably 6 or more of genes and/or proteins, and most
preferably 12 or more of genes and/or proteins, that are indicative of
cancer recurrence.