The present invention relates to a cooling module retentioner, which includes a fixing base and a flexible frame. The fixing base surrounds a heat-generating electronic component at a center and allows the placement of a cooling module therein, and a rising corner column is disposed at each of four corners thereof and each corner column has a snap hole; the flexible frame is composed of two M-like retention brackets whose bottom sides are mounted with a retention hook respectively for the corresponding snap hole, a lever is pivotally disposed at a lower center location thereof and pertains to a metal rod whose one end is integrally bent to form a protruded portion. The production process requires no mold so as to simplify the production process and reduce the production cost.