A system controller communicates with devices in a serial interconnection. The system controller sends a read command, a device address identifying a target device in the serial interconnection and a memory location. The target device responds to the read command to read data in the location identified by the memory location. Read data is provided as an output signal that is transmitted from a last device in the serial interconnection to a data receiver of the controller. The data receiver establishes acquisition instants relating to clocks in consideration of a total flow-through latency in the serial interconnection. Where each device has a clock synchronizer, a propagated clock signal through the serial interconnection is used for establishing the acquisition instants. The read data is latched in response to the established acquisition instants in consideration of the flow-through latency, valid data is latched in the data receiver.