Responding to IO requests made by an application to an operating system within a computing device implements IO performance acceleration that interfaces with the logical and physical disk management components of the operating system and within that pathway provides a system memory based disk block cache. The logical disk management component of the operating system identifies logical disk addresses for IO requests sent from the application to the operating system. These addresses are translated to physical disk addresses that correspond to disk blocks available on a physical storage resource. The disk block cache stores cached disk blocks that correspond to the disk blocks available on the physical storage resource, such that IO requests may be fulfilled from the disk block cache. Provision of the disk block cache between the logical and physical disk management components accommodates tailoring of efficiency to any applications making IO requests, and flexible interaction with various different physical disks.