An IL-1.beta. binding antibody or IL-1.beta. binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1.beta. binding antibodies or IL-1.beta. binding fragments thereof are provided which have desirable affinity and potency.