The present invention relates to a process for the purification of
antibodies from one or more impurities in a liquid, which process
comprises contacting said liquid with a first chromatography resin
comprised of a support to which multi-modal ligands have been immobilised
to adsorb the antibodies to the resin, wherein each multi-modal ligand
comprises at least one cation-exchanging group and at least one aromatic
or heteroaromatic ring system; adding an eluent to release the antibodies
from the resin; and contacting the eluate so obtained with a second
chromatography resin. In one embodiment, the ring-forming atoms of the
aromatic or heteroaromatic entity are selected from the group consisting
of C, S and O, and the cation exchanging group is a weak cation
exchanger.