The present invention provides a microorganism useful for biologically
producing 1,3-propanediol from a fermentable carbon source at higher
yield than was previously known. The complexity of the cofactor
requirements necessitates the use of a whole cell catalyst for an
industrial process that utilizes this reaction sequence to produce
1,3-propanediol. The invention provides a microorganism with disruptions
in specified genes and alterations in the expression levels of specified
genes that is useful in a higher yielding process to produce
1,3-propanediol.