A lotion bottle fixing base unit, comprising a base, a fixing unit, an IC circuit set and a silicone rubber washer. The base and fixing unit are extrusion formed plastics. The IC circuit set is installed in the round groove on the base. The silicone rubber washer is installed at an appropriate location on the base. The covering groove at the lower part of the fixing unit serves to cover the entire base. The bottle fixing groove on the upper part of the fixing unit serves to accommodate a lotion bottle or similar bottle or container. A daily-use bottle can be fixed by the user to the base, so that when the user presses on the lotion bottle on the fixing unit, the fixing unit will activate the flexible switch, and the base will produce music to entertain the user.