In accordance with the present invention, there is provided a class of
pyridine compounds which are modulators of acetylcholine receptors. The
compounds of the invention displace acetylcholine receptor ligands from
their binding sites. Invention compounds may act as agonists, partial
agonists, antagonists or allosteric modulators of acetylcholine receptors,
and are useful for a variety of therapeutic applications, such as the
treatment of Alzheimer's disease and other disorders involving memory loss
and/or dementia (including AIDS dementia); disorders of attention and
focus (such as attention deficit disorder); disorders of extrapyramidal
motor function such as Parkinson's disease, Huntington's disease, Gilles
de la Tourette syndrome and tardive dyskinesia; mood and emotional
disorders such as depression, panic, anxiety and psychosis; substance
abuse including withdrawal syndromes and substitution therapy;
neuroendocrine disorders and dysregulation of food intake, including
bulimia and anorexia; disorders of nociception and control of pain;
autonomic disorders including dysfunction of gastrointestinal motility and
function such as inflammatory bowel disease, irritable bowel syndrome,
diarrhea, constipation, gastric acid secretion and ulcers;
pheochromocytoma; cardiovascular dysfunction including hypertension and
cardia arrhythmias, comedication in surgical procedures, and the like.
De acordo com a invenção atual, é fornecido uma classe dos compostos do pyridine que são moduladores dos receptors do acetylcholine. Os compostos da invenção deslocam ligands do receptor do acetylcholine de seus locais obrigatórios. Os compostos da invenção podem agir como os agonists, os agonists parciais, os antagonistas ou moduladores allosteric dos receptors do acetylcholine, e são úteis para uma variedade de aplicações therapeutic, tais como o tratamento da doença de Alzheimer e outros disorders que envolvem a perda e/ou o dementia da memória (dementia including do AIDS); disorders da atenção e do foco (tais como o disorder de deficit de atenção); os disorders do motor extrapiramidal funcionam como a doença de Parkinson, a doença de Huntington, o syndrome de Gilles de la Tourette e a discinesia tardive; modo e disorders emocionais tais como o depression, o pânico, a ansiedade e o psychosis; abuso da substância including syndromes da retirada e terapia da substituição; disorders do neuroendocrine e dysregulation da entrada de alimento, including o bulimia e o anorexia; disorders do nociception e controle da dor; disorders autonomic including o dysfunction do motility e da função gastrointestinal tal como a doença inflammatory do bowel, o syndrome irritable do bowel, o diarrhea, o constipation, o secretion ácido gastric e os ulcers; pheochromocytoma; dysfunction cardiovascular including arrhythmias do hypertension e do cardia, comedication em procedimentos cirúrgicos, e o gosto.
