This invention provides compounds of Formula I having the structure
##STR1##
E is S, SO, SO.sub.2, O, or NR.sup.1c ;
X is hydrogen, halogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon
atoms, CN, aryl, aralkyl of 6-12 carbon atoms, hydroxyalkyl of 1-6 carbon
atoms, hydroxyaralkyl of 6-12 carbon atoms, perfluoroalkyl of 1-6 carbon
atoms, alkoxy of 1-6 carbon atoms, aryloxy; arylalkoxy, nitro, amino,
NR.sup.2 R.sup.2a, NR.sup.2 COR.sup.2a, cycloalkylamino of 3-8 carbon
atoms, morpholino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl,
pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, --OCH.sub.2 CO.sub.2
R.sup.2b or --COR.sup.2c ;
Z.sup.1 and Z.sup.2 are each, independently, hydrogen, halogen, CN, alkyl
of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8
carbon atoms, nitro, amino, --NR.sup.1 R.sup.1a, --NR.sup.1 COR.sup.1a,
cycloalkylamino of 3-8 carbon atoms, morpholino, or OR.sup.8, or Z.sup.1
and Z.sup.2 may be taken together as a diene unit having the formula
--CH.dbd.CR.sup.9 --CR.sup.10.dbd.CR.sup.11 --;
or a pharmaceutically acceptable salt thereof, which are useful in treating
metabolic disorders related to insulin resistance or hyperglycemia.
Esta invenção fornece compostos da fórmula I que têm o ## E do ## STR1 da estrutura é S, ASSIM, SO.sub.2, O, ou NR.sup.1c; X são hidrogênio, halogênio, alkyl de 1-6 átomos de carbono, alkenyl de 2-7 átomos de carbono, CN, arilo, aralkyl de 6-12 átomos de carbono, hydroxyalkyl de 1-6 átomos de carbono, hydroxyaralkyl de 6-12 átomos de carbono, perfluoroalkyl de 1-6 átomos de carbono, alkoxy de 1-6 átomos de carbono, aryloxy; arylalkoxy, nitro, amino, NR.sup.2 R.sup.2a, NR.sup.2 COR.sup.2a, cycloalkylamino de 3-8 átomos de carbono, morpholino, alkylsulfanyl de 1-6 átomos de carbono, arylsulfanyl, pyridylsulfanyl, 2-N, N-dimethylaminoethylsulfanyl, -- OCH.sub.2 CO.sub.2 R.sup.2b ou -- COR.sup.2c; Z.sup.1 e Z.sup.2 são cada um, independentemente, hidrogênio, halogênios, CN, alkyl de 1-6 átomos de carbono, arilo, aralkyl de 6-12 átomos de carbono, cycloalkyl de 3-8 átomos de carbono, nitro, amino, -- NR.sup.1 R.sup.1a, -- de NR.sup.1 COR.sup.1a, cycloalkylamino de 3-8 átomos de carbono, morpholino, ou OR.sup.8, ou Z.sup.1 e Z.sup.2 podem ser feitos exame junto como uma unidade do diene que tem a fórmula -- CH.dbd.CR.sup.9 -- O --; CR.sup.10.dbd.CR.sup.11 ou um sal pharmaceutically aceitável disso, que são úteis em disorders metabolic de tratamento relacionaram-se à resistência de insulin ou ao hyperglycemia.
