The present invention provides a compound of the formula
##STR1##
wherein when X is S; R is selected from the group consisting of CH.sub.3,
CH.sub.2 CH.sub.3, CH.sub.2 Ph, (CH.sub.2).sub.2 Ph, (CH.sub.2).sub.2
CH.sub.3, (CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.4 CH.sub.3,
CH.sub.2).sub.5 CH.sub.3, (CH.sub.2).sub.6 CH.sub.3, (CH.sub.2).sub.2
O(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 HC.dbd.CH(CH.sub.2).sub.3 CH.sub.3,
CH.sub.2 C.ident.C(CH.sub.2).sub.3 CH.sub.3, CH.sub.2
C.ident.C(CH.sub.2).sub.2 CH.sub.3, CH.sub.2 C.ident.CCH.sub.2 CH.sub.3,
CH.sub.2 C.ident.CCH.sub.3, CH.sub.2 C.ident.CH, CH.sub.2
C.ident.C(CH.sub.2).sub.4 CH.sub.3, CH.sub.2 C.ident.C(CH.sub.2).sub.5
CH.sub.3, CH.sub.2 C.ident.C(CH.sub.2).sub.6 CH.sub.3, (CH.sub.2).sub.2
C.ident.C(CH.sub.2).sub.2 CH.sub.3, CH(Ch.sub.3)C.ident.C(CH.sub.2).sub.3
CH.sub.3, (CH.sub.2).sub.6 I, (CH.sub.2).sub.6 Br, (CH.sub.2).sub.5 Br,
(CH.sub.2).sub.5 COOH and (CH.sub.2).sub.5 OCOCH.sub.3, and R' is selected
from the group consisting of CH.sub.3, CF.sub.3, CH.sub.2 Cl, CH.sub.2 Br,
CH.sub.2 CH.sub.3, NH.sub.2, and OSO.sub.2 CH.sub.3 ; wherein when R is
CH.sub.3, R' can not be CH.sub.3 or CH.sub.2 Cl; wherein when R is
CH.sub.2 CH.sub.3, R' can not be CH.sub.3 ; wherein when X is Se, R is
(CH.sub.2).sub.6 CH.sub.3, and R' is CH.sub.3 or a pharmaceutically
acceptable salt or hydrate thereof; and wherein when X is O, R is CH.sub.2
C.ident.C(CH.sub.2).sub.3 CH.sub.3, and R' is CH.sub.3 or a
pharmaceutically acceptable salt or hydrate thereof. Also provided is a
method of inhibiting the synthesis of prostaglandin endoperoxide
synthase-2 (PGHS-2) in a mammal.
Присытствыющий вымысел обеспечивает смесь ## ## STR1 формулы при котором когда х будет с; Р выбран от группы consist of CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 ph, (CH.sub.2).sub.2 ph, (CH.sub.2).sub.2 CH.sub.3, (CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.4 CH.sub.3, CH.sub.2).sub.5 CH.sub.3, (CH.sub.2).sub.6 CH.sub.3, (CH.sub.2).sub.2 O(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 HC.dbd.CH(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C.ident.C(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C.ident.C(CH.sub.2).sub.2 CH.sub.3, CH.sub.2 C.ident.CCH.sub.2 CH.sub.3, CH.sub.2 C.ident.CCH.sub.3, CH.sub.2 C.ident.CH, CH.sub.2 C.ident.C(CH.sub.2).sub.4 CH.sub.3, CH.sub.2 C.ident.C(CH.sub.2).sub.5 CH.sub.3, CH.sub.2 C.ident.C(CH.sub.2).sub.6 CH.sub.3, (CH.sub.2).sub.2 C.ident.C(CH.sub.2).sub.2 CH.sub.3, CH(Ch.sub.3)C.ident.C(CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.6 ii1, (br CH.sub.2).sub.6, (br CH.sub.2).sub.5, (CH.sub.2).sub.5 COOH и (CH.sub.2).sub.5 OCOCH.sub.3, и р ' выбраны от группы consist of CH.sub.3, CF.sub.3, CH.sub.2 cl, CH.sub.2 br, CH.sub.2 CH.sub.3, NH.sub.2, и OSO.sub.2 CH.sub.3; при котором когда р будет CH.sub.3, р ' не может быть cl CH.sub.3 или CH.sub.2; при котором когда р будет CH.sub.2 CH.sub.3, р ' не может быть CH.sub.3; при котором когда х будет se, р (CH.sub.2).sub.6 CH.sub.3, и р ' будут CH.sub.3 или фармацевтически приемлемо солью или гидратом thereof; и при котором когда х будет о, р будет CH.sub.2 C.ident.C(CH.sub.2).sub.3 CH.sub.3, и р ' CH.sub.3 или фармацевтически приемлемо соль или гидрат thereof. Также обеспечен метод блокировать синтез endoperoxide synthase-2 простагландина (PGHS-2) в mammal.
