The present invention provides a novel complex of hK2 and PI-6 and methods
of using the novel complex. The novel complexes of hK2 and PI-6 of the
present invention exist at an elevated level in prostate cancer tissues.
Therefore, the hK2-PI6 complexes of the present invention may be used as a
serum marker for detecting prostate cancer. They may also be used as an
immunohistological marker to detect prostate cancer tissues. In accordance
with the present invention, the hK2-PI6 complexes of the present invention
may be detected in patient tissue samples by immunohistochemical and/or in
patient fluid samples by in vitro immunoassay procedures. Diagnostic kits
and diagnostic methods for detecting the existence of prostate cancer are
also provided.