Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

Os compostos receptor-modulando do pyrazole do estrogen são descritos além aos métodos e às composições para tratar ou impedir disorders receptor-mediados estrogen. Os compostos descritos foram encontrados para ter atividade inesperada e surpreendendo na atividade modulando do receptor do estrogen. Assim, os compostos da invenção atual têm a utilidade em disorders receptor-mediados estrogen impedindo ou de tratamento tais como o osteoporosis, o peito e cancers endometrial, atherosclerosis, e doença de Alzheimer.

 
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