Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and
immunoeffectors are described and claimed. The compounds have a
2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon)
group. Compounds are phosphorylated at the 4 or 6 carbon on the
glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The
compounds augment antibody production in immunized animals as well as
stimulate cytokine production and activate macrophages. Methods for using
the compounds as adjuvants and immunoeffectors are also disclosed.
Os compostos do phosphate do glucosaminide do aminoalkyl (AGP) que são adjutores e immunoeffectors são descritos e reivindicados. Os compostos têm um glucose 2-deoxy-2-amino no enlace glycosidic com um grupo do aminoalkyl (aglycon). Os compostos são phosphorylated no carbono 4 ou 6 no anel do glucosaminide e compreendem três resíduos 3-alkanoyloxyalkanoyl. Os compostos aumentam a produção do antibody em animais immunized as.well.as estimulam a produção do cytokine e ativam macrophages. Os métodos para usar os compostos como adjutores e immunoeffectors são divulgados também.