Universal, biocompatible coating platforms for articles intended to contact physiological fluids or tissues and associated methods of production are disclosed. The coating platforms of the present invention are composed of a polyelectrolyte molecular film containing one or more biologically active compounds. The molecular film is further complexed with the surface of an article by a crosslinked interpenetrating network (IPN) made from at least one multifunctional molecule and at least one crosslinking agent. The IPN may entrap additional biologically active compounds within the coating platform, or additional biologically active compounds may be bound to its outer surface. The coating platform of the present invention is ideally suited for providing medical devices with anti-thrombogenic coatings.