A process for real-time reconfiguring of trajectories or airborne vehicles in order to adapt a mission to suit a new situation that has arisen through the occurrence of a disrupting event. The process updates real-time context data modified by the occurrence of the disrupting event and analyzes the new real-time context thus obtained in order to select a predefined reconfiguration method chosen from a set of different predefined methods stored in memory, each of these methods directly translating operational strategies customarily employed by aircrew in a given real-time context so as to determine a new trajectory which best suits the current real-time context. The process then executes the selected predefined method, which determines a new trajectory according to the mission data and the real-time context, displays the new trajectory on a display, overlayed on the current trajectory and, if the pilot of the airborne vehicle validates this new trajectory, transmits the information of this new trajectory to an automatic pilot device.