The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating with an electrophilic reagent which provides Q1, or a functional moiety which is then transformed to Q1, producing 1-bromo-2,4-difluoro-3-Q1-benzene; (b) treating the 1-bromo-2,4-difluoro-3-Q1-benzene with an alkali or alkaline earth metal or organometallic reagent; then treating with carbon dioxide, or with a formylating agent followed by oxidation, to produce 2,4-difluoro-3-Q1-benzoic acid. The subject invention also involves optional additional steps to further modify Q1, or to substitute a non-hydrogen moiety at the 5-position, at the 6-position, or at both, of the phenyl ring of the 2,4-difluoro-3-Q1-benzoic acid.

A invenção sujeita envolve os processos para fazer o ácido 2,4-difluoro-3-Q1-benzoic, wherein Q1 é derivado de um reagent electrophilic, compreendendo as etapas de: (a) 1-bromo-2,4-difluorobenzene de tratamento com uma base forte, non-non-nucleophilic; então tratando com um reagent electrophilic que forneça Q1, ou um moiety funcional que seja transformado então a Q1, produzindo 1-bromo-2,4-difluoro-3-Q1-benzene; (b) tratando o 1-bromo-2,4-difluoro-3-Q1-benzene com um alcalóide ou um reagent alcalino-térreo ou organometallic; então tratando com o dióxido de carbono, ou com um agente formylating seguido pela oxidação, para produzir o ácido 2,4-difluoro-3-Q1-benzoic. A invenção sujeita envolve também etapas adicionais opcionais para modificar mais mais Q1, ou para substituir um moiety do non-hidrogênio no 5-position, no 6-position, ou em ambos, o anel phenyl do ácido 2,4-difluoro-3-Q1-benzoic.