Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Bepaalde zes-membered aromatische en heteroaromatic-dioxobutyric zure derivaten worden beschreven als inhibitors van HIV integrase en inhibitors van HIV replicatie. Deze samenstellingen zijn nuttig in de preventie of de behandeling van besmetting door HIV en de behandeling van AIDS, of als samenstellingen, farmaceutisch aanvaardbare zouten, farmaceutische samenstellingsingrediënten, al dan niet in combinatie met andere antivirals, immunomodulators, antibiotica of vaccins. De methodes om AIDS te behandelen en de methodes om besmetting te verhinderen of te behandelen door HIV worden ook beschreven.