The present invention relates to a isolated leukaemia inhibitory factor (LIF)-binding protein (LBP) in soluble form and obtainable from a first mammalian species, said LBP capable of inhibiting the ability of LIF from a second mammalian species to induce differentiation of M1 myeloid leukaemic cells in vitro to a greater extent when compared to its ability to inhibit LIF from said first mammalian species.

A invenção atual relaciona-se a um fator inhibitory isolado do leukaemia (a proteína LIF)-ligando (LBP) no formulário soluble e obtenível de uma primeira espécie mammalian, disse LBP capaz de inibir a abilidade de LIF de uma segunda espécie mammalian de induzir o differentiation das pilhas M1 leukaemic myeloid em vitro a uma extensão mais grande quando comparada a sua abilidade de inibir LIF das primeiras espécies mammalian ditas.

 
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