Provided are methods for detecting membrane derived apoptotic activity. In one embodiment, the present invention provides methods for identifying membrane derived caspase activity. In other embodiments, drug discovery methods are provided for screening compounds that inhibit or enhance membrane derived caspase activity. In the various embodiments, heavy membrane fractions are utilized for the screening methodologies described herein.

 
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< Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes

< MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use

> C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases

> Mch4 and Mch5, apoptotic protease, nucleic acids encoding and methods of use
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