This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.

Esta invenção é dirigida aos compostos tricyclic do inibidor da família ICE/ced-3 da novela. A invenção é dirigida também às composições pharmaceutical de tais compostos tricyclic, mais o uso de tais composições no tratamento dos pacientes doenças inflammatory, autoimmune e neurodegenerative sofrendo, e para a prevenção de ferimento isquêmico.
 
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< Inhibition of apoptosis using interleukin-1.beta.-converting enzyme (ICE)/CED-3 family inhibitors

< Treatment of infectious disease using interleukin-1.beta.-converting enzyme (ICE)/CED-3 family inhibitors

> MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use

> Methods for detecting membrane derived caspase activity and modulators thereof
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