Disclosed are compounds which bind .alpha..sub.4.beta..sub.7 integrin.
Certain of these compounds also inhibit leukocyte adhesion and, in
particular, leukocyte adhesion mediated by .alpha..sub.4.beta..sub.7
integrin. Such compounds are useful in the treatment of inflammatory
diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's
disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel
disease, rheumatoid arthritis, tissue transplantation, tumor metastasis
and myocardial ischemia. The compounds can also be administered for the
treatment of inflammatory brain diseases such as multiple sclerosis.