The instant invention provides compound of formula I
##STR1##
wherein:
R.sup.1 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --O--CO--(C.sub.1
-C.sub.6 alkyl), --O--CO--O(C.sub.1 -C.sub.6 alkyl), --O--CO--Ar in which
Ar is optionally substituted phenyl, or --O--SO.sub.2 --(C.sub.4 -C.sub.6
alkyl);
R.sup.2 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --O--CO--(C.sub.1
-C.sub.6 alkyl), --O--CO--O(C.sub.1 -C.sub.6 alkyl), --O--CO--Ar in which
Ar is optionally substituted phenyl, --O--SO.sub.2 --(C.sub.4 -C.sub.6
alkyl), --F, --Cl, or --Br;
n is an integer from 5 to 8;
R.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, or
combine to form, with the nitrogen to which they are attached,
piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or
hexamethyleneimino;
or a pharmaceutically acceptable salt or solvate thereof, intermediates,
pharmaceutical formulations, processes, and methods of use.
