The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

A invenção atual relaciona-se a três proteínas obrigatórias do recognition peptidoglycan da novela expressadas por keratinocytes, por tecidos ferida-wound-healing e por tecido do chondrosarcoma. Mais especificamente, as moléculas isoladas do ácido nucleic são fornecidas que codificam as proteínas proteína-relacionadas do recognition peptidoglycan humano, consultadas a nisto como PGRP-K (Keratinocytes), o PGRP-W (Ferida-wound-healing), e o PGRP-C (Chondrosarcoma) dos FIGS. 1A-B, FIGS. 2A-C, e FIG. 3, respectivamente, cada um que tem o homology aos ambos proteína peptidoglycan humana do recognition (PGRP) as.well.as Tag-7 murine. Os polypeptides de PGRP-K, de PGRP-W, e de PGRP-C são fornecidos também. São fornecidos mais mais os vetores, as pilhas de anfitrião e os métodos recombinant para produzir o mesmo. A invenção relaciona-se também à inibição e realce das atividades de PGRP-K, PGRP-W, e polypeptides de PGRP-c e métodos diagnósticos para detectar expressão do gene de PGRP-K, de PGRP-W, e de PGRP-C.