The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I). ##STR1##

De onderhavige uitvinding heeft op nieuwe agenten tegen kanker, hun stereo-isomeren, hun polymorphs, hun farmaceutisch aanvaardbare zouten, en hun farmaceutisch aanvaardbare solvates betrekking. De onderhavige uitvinding heeft meer in het bijzonder op nieuwe derivaten van andrographolide, hun stereo-isomeren, hun polymorphs, hun farmaceutisch aanvaardbare zouten, en hun farmaceutisch aanvaardbare solvates betrekking. De nieuwe derivaten van andrographolide hebben de algemene formule (I). ## STR1 ##