The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr.sub.10 -contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

La actual invención se dirige al contulakin-G (que es el peptide glycosylated nativo), un contulakin-G DES-DES-GLYCOSYLATED (llamado Thr.sub.10 - contulakin-G), y derivados de eso, a una copia de la DNA que codifica un precursor de este peptide maduro y a un peptide del precursor. La invención se dirige más a fondo al uso de este peptide como un terapéutico para el contra-asimiento, antiinflamatorio, antichoque, el contra-trombo, hipotenso, analgesia, anti-psychotic, enfermedad de Parkinson, desórdenes gastrointestinales, estados depresivos, disfunción cognoscitiva, ansiedad, discinesia tardive, dependencia de la droga, ataque del pánico, mania, síndrome irritable del intestino, diarrea, úlcera, tumores del SOLDADO ENROLADO EN EL EJÉRCITO, síndrome de Tourette, corea de Huntington, desórdenes vasculares de la salida, de la contra-arteriosclerasis, vasculares y de la vasodilatación, así como desórdenes neurológicos, neuropharmalogical y neuropsychopharmacological.

 
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