This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Esta invenção relaciona-se aos compostos neurotrophic que têm uma afinidade para o FKBP-tipo immunophilins, sua preparação e uso como inibidores da atividade de enzyme associada com as proteínas do immunophilin, e particularmente inibidores da atividade peptidyl-prolyl-prolyl do isomerase ou de enzyme do rotamase.