This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury.

Esta invenção é dirigida aos compostos (n-substituted) do indole ICE/ced-3-inhibitor da novela. A invenção é dirigida também às composições pharmaceutical de tais compostos do indole, mais o uso de tais composições no tratamento dos pacientes doenças inflammatory, autoimmune e neurodegenerative sofrendo, para a prevenção de ferimento isquêmico.
 
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> Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes

> (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
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