This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

Cette invention est dirigée vers le roman (composés d'inhibiteur de famille de dipeptidyl ICE/ced-3 de substituted)acyl. L'invention est également dirigée vers les compositions pharmaceutiques contenant ces composés, aussi bien que l'utilisation de telles compositions dans le traitement des patients les maladies inflammatoires, autoimmunes et neurodegenerative de souffrance, pour la prévention des dommages ischémiques, et pour la conservation des organes qui doivent subir un procédé de transplantation.
 
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< C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases

< Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes

> Rapid methods for identifying modifiers of cellular apoptosis activity

> Inhibition of inflammation using interleukin-1.beta.-converting enzyme (ICE)/CED-3 family inhibitors
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