Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic aromatic compounds have the structure ##STR1## including pharmaceutically acceptable salts thereof and all stereoisomers thereof, wherein X.sub.a is heteroaryl, preferably, ##STR2## and R.sub.1, R.sub.1a, R.sub.6, Y, X.sub.b, A, B, Z, R.sub.3, R.sub.4, R.sub.4a, R.sub.5 and R.sub.5a are as defined herein.

Os compostos aromatic heterocyclic são fornecidos que são úteis em estimular a produção ou a liberação endogenous do hormone do crescimento e no obesity de tratamento, osteoporosis (que melhora a densidade do osso) e em melhorar a massa do músculo e a força de músculo. Os compostos aromatic heterocyclic têm o ## do ## STR1 da estrutura including sais pharmaceutically aceitáveis disso e todos os stereoisomers disso, wherein X.sub.a são heteroaryl, preferivelmente, ## do ## STR2 e R.sub.1, R.sub.1a, R.sub.6, Y, X.sub.b, A, B, Z, R.sub.3, R.sub.4, R.sub.4a, R.sub.5 e R.sub.5a são como definidos nisto.

 
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