Methods and compositions, useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's Disease (AD). These methods involve administering to a subject a pharmaceutical composition including one or more agents which modulate APP catabolism and amyloid deposition. Accordingly, the methods and compositions are useful for inhibiting amyloidosis in disorders in which amyloid deposition occurs. The methods are based, at least in part, on modulating catabolism of APP in APP-containing cells through the use of a mobile ionophore, such as carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone, which does not substantially alter the viability of those cells.

Os métodos e as composições, úteis no tratamento do amyloidosis e as circunstâncias e as doenças associaram therewith, como a doença de Alzheimer (ANÚNCIO). Estes métodos envolvem administrar a um assunto uma composição pharmaceutical including um ou mais agente que modulam o deposition do catabolism e do amyloid do APP. Conformemente, os métodos e as composições são úteis para inibir o amyloidosis nos disorders em que o deposition amyloid ocorre. Os métodos são baseados, ao menos na parte, no catabolism modulando do APP em pilhas APP-contendo com o uso de um ionophore móvel, tal como o p-(trifluoromethoxy)phenylhydrazone do cianido do carbonyl, que não altera substancialmente o viability daquelas pilhas.